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  • 1 month later...

Researchers discover underlying cause of brain fog linked with long COVID

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A team of scientists from Trinity College Dublin and investigators from FutureNeuro has announced a major discovery with profound importance for our understanding of brain fog and cognitive decline seen in some patients with long COVID. The work appears in Nature Neuroscience.

In the months after the emergence of the novel coronavirus SARS-CoV2 in late 2019 a patient-reported syndrome termed long COVID began to come to the fore as an enduring manifestation of acute infection.

Long COVID has up to 200 reported symptoms to date, but in general, patients report lingering symptoms such as fatigue, shortness of breath, problems with memory and thinking and joint/muscle pain. While the vast majority of people suffering from COVID-19 make a full recovery, any of these symptoms that linger for more than 12 weeks post infection can be considered long COVID.

Long COVID has now become a major public health issue since the outbreak of the pandemic in 2020. While international incidence rates vary, it is estimated to affect up to 10% of patients infected with the SARS-CoV2 virus. Of these patients suffering from long COVID, just under 50% of them report some form of lingering neurological effect such as cognitive decline, fatigue and brain fog.

Now, the findings reported by the Trinity team have shown that there was disruption to the integrity of the blood vessels in the brains of patients suffering from long COVID and brain fog. This blood vessel "leakiness" was able to objectively distinguish those patients with brain fog and cognitive decline compared to patients suffering from long COVID but not with brain fog.

The team led by scientists at the Smurfit Institute of Genetics in Trinity's School of Genetics and Microbiology and neurologists in the School of Medicine have also uncovered a novel form of MRI scan that shows how long COVID can affect the human brain's delicate network of blood vessels.

 

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  • 3 weeks later...
  • 2 months later...

‘Unusual’ cancers emerged after the pandemic. Doctors ask if covid is to blame.

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Kashyap Patel looked forward to his team’s Friday lunches. All the doctors from his oncology practice would gather in the open-air courtyard under the shadow of a tall magnolia tree and catch up. The atmosphere tended to the lighthearted and optimistic. But that week, he was distressed.

It was 2021, a year into the coronavirus pandemic, and as he slid into a chair, Patel shared that he’d just seen a patient in his 40s with cholangiocarcinoma, a rare and lethal cancer of the bile ducts that typically strikes people in their 70s and 80s. Initially, there was silence, and then one colleague after another said they’d recently treated patients who had similar diagnoses. Within a year of that meeting, the office had recorded seven such cases.

“I’ve been in practice 23 years and have never seen anything like this,” Patel, CEO of Carolina Blood and Cancer Care Associates, later recalled. Asutosh Gor, another oncologist, agreed: “We were all shaken.”

There was other weirdness, too: multiple patients contending with multiple types of cancer arising almost simultaneously, and more than a dozen new cases of other rare cancers.

Increasingly, Patel was left with an unsettling thought: Could the coronavirus be inflaming the embers of cancer?
The uptick in aggressive, late-stage cancers since the dawn of the pandemic is confirmed by some early national data and a number of large cancer institutions. Many experts have mostly dismissed the trend as an expected consequence of disruptions to health care that began in 2020.

But not everyone.

The idea that some viruses can cause or accelerate cancer is hardly new. Scientists have recognized this possibility since the 1960s, and today, researchers estimate 15 to 20 percent of all cancers worldwide originate from infectious agents such as HPV, Epstein-Barr and hepatitis B.

It will probably be many years before the world has conclusive answers about whether the coronavirus is complicit in the surge of cancer cases, but Patel and other concerned scientists are calling on the U.S. government to make this question a priority knowing it could affect treatment and management of millions of cancer patients for decades to come.

“We are completely under-investigating this virus,” said Douglas C. Wallace, a University of Pennsylvania geneticist and evolutionary biologist. “The effects of repeatedly getting this throughout our lives is going to be much more significant than people are thinking.”



About a year ago Beheshti, a visiting researcher at MIT and Harvard’s Broad Institute, reached out to Patel, who is a past president of the Community Oncology Alliance, a national group of independent cancer specialists, and they hosted a symposium with other scientists that concluded compelling evidence exists suggesting links between the coronavirus and cancer.

“Hopefully, we’re wrong,” Beheshti said. “But everything is, unfortunately, pushing toward that being the case.”

 

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It should also be pointed out that the central premise of the original meme is false -- you can drink pretty much any vaccine and be perfectly fine. The effects will be dramatically diminished due to your digestive tract reducing and/or blocking the vaccine from entering the bloodstream, but otherwise there is as much ill-effect as drinking saline.

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9 hours ago, Simon said:

It should also be pointed out that the central premise of the original meme is false -- you can drink pretty much any vaccine and be perfectly fine. The effects will be dramatically diminished due to your digestive tract reducing and/or blocking the vaccine from entering the bloodstream, but otherwise there is as much ill-effect as drinking saline.

 

IIRC, when I was a kid, I got a vaccine orally, with a sugar cube.  MMR or polio...I can't recall.  That's if I ever knew.  This is early 60s stuff, so could be either.  
 

The first speaker in the meme is a total idiot, but unfortunately, his brand of stupid is much too common. 

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2 hours ago, unclevlad said:

I'll grant that one jab is more pleasant than 2, but why do I think they're doing it because they can take the $A charge for the flu, $B for the Covid, then make it 1.5 * ($A+$B) for the combined shot? 

 

Because you're a bitter, cynical old man? :winkgrin:

 

I'm grateful that we Canadians don't have to worry about the cost of vaccines.

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  • 4 weeks later...

I took my last dose of Paxlovid last night. I'm glad of it; the medicine gave me a horrible aftertaste that stayed with me.

 

However, I feel absolutely wretched today. I've been nauseous all day, so I'm taking the time to take care of myself. Nothing strenuous or stressful. I'll deal with the outside world tomorrow.

 

I have lost a few pounds, which I have been trying to do, but this isn't a healthy way to do it.

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